A mutation frequency map of the transcriptional activator [____] core domain sho

Question

A mutation frequency map of the transcriptional activator [____] core domain shows the amino acid residues most frequently mutated in human [_____]. The six most frequently mutated residues are within three of the four most highly conserved domains, which contain the protein's arginine residues that interact with the [____]. These specific mutations, caused by agents such as [____], occur within [____] base pairs, converting them to [____] base pairs.

(1) p53, cancer, p21 protein, cytochrome P-450, guanine, adenine

(2) RB, retinoblastoma, E2F protein, benzo(a)pyrene, CG, AT

(3) p53, tumors, DNA helix, aflatoxin B1, guanine-cytosine, adenine-thymine

(4) p21, colon cancer, DNA helix, nitrites, AT, GC

(5) PrPc, amyloid disease, neuron, prions, cytosine-guanine, thymine-adenine

Explanation / Answer

(5) PrPc, amyloid disease, neuron, prions, cytosine-guanine, thymine-adenine

A mutation frequency map of the transcriptional activator [_PrPc___] core domain shows the amino acid residues most frequently mutated in human [_amyloid disease]. The six most frequently mutated residues are within three of the four most highly conserved domains, which contain the protein's arginine residues that interact with the [_neuron___]. These specific mutations, caused by agents such as [prions____], occur within [_cytosine-guanine___] base pairs, converting them to [_thymine-adenine__] base pairs.

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