Linkage looks at tha relationship of specific loci on a chromosome. Genome wide

Question

Linkage looks at tha relationship of specific loci on a chromosome. Genome wide association studies attempt to determine statistical relationship between genetic changes and a disease or other phenotype you have carried out a GWAS for 'stand directly in front of the closing door syndrome' which causes people to cluster by the subway door even when there is room in the center of the car you found a positive correlation with a haplotype cluster however. As a careful resarcher, you are cautious in interpreting you results last two reasons that your GWAS might yield a false positive result.

Explanation / Answer

Reason:-

This approach is known as phenotype-first, in which the participants are classified first by their clinical manifestation(s), as opposed to genotype-first. Each person gives a sample of DNA, from which millions of genetic variants are read using SNP arrays. If one type of the variant (one allele) is more frequent in people with the disease, the variant is said to be associated with the disease. The associated SNPs are then considered to mark a region of the human genome that may influence the risk of disease. In contrast to methods that specifically test one or a few genetic regions, the GWA studies investigate the entire genome. The approach is therefore said to be non-candidate-driven in contrast to gene-specific candidate-driven studies. GWA studies identify SNPs and other variants in DNA associated with a disease, but that cannot on their own specify which genes are causal.

haplotype clustering offers an appealing solution. In this research a new befitting haplotype similarity for "affinity propagation" clustering algorithm, which can account for the rare haplotypes primely, so as to control for the issue on degrees of freedom. The new similarity can incorporate haplotype structure information, which is believed to enhance the power and provide high resolution for identifying associations between genetic variants and disease.

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