) Recall that the renal clearance of substance X is calculated using C X = (U X

ID: 72440 • Letter: #

Question

) Recall that the renal clearance of substance X is calculated using

CX = (UX)(V)/PX

Creatinine, a metabolite of creatine, is generated at roughly a constant rate by muscle.

The following measurements were made (a deciliter, dL, is one tenth of a liter or 100 milliliters):

Plasma inulin concentration = 1 mg/dL

Urine inulin concentration = 100mg/dL

Plasma creatinine concentration = 1mg/dL

Urine creatinine concentration = 117 mg/dL

The flow of urine (V) was 1.2 ml/min or 1.2 x 10-2 dL/min.

Calculate the glomerular filtration rate. Express it in ml per min.

Calculate the clearance of creatinine (also in ml/min).

What can you conclude about the fate of creatinine in the kidney?

GFR (mL/min/1.73 m2) = 175 × (Scr)-1.154 × (Age)-0.203 × (0.742 if female) × (1.212 if African American)

Scr:urine creatinine

on calculating,glomerular filtration rate for 25 year old female will be= 0.3 ml/min

2. Creatinine Clearance = [[140 - age(yr)]*weight(kg)]/[72*serum Cr(mg/dL)]
(multiply by 0.85 for women).

therefore for female of 25 years, and weight 50 kg the creatinine clearance rate will be: 67.88 mL/min

3. As we can see the rate of creatinine clearance is 67.88 mL/min and the urine creatinine is 117mg/dl or 1.17 mg/ml.

normal clearence rate of women lie between 88-128 mL/min. So the kidney will develop stone after some time as there is deposition of creatinine.

So there will be full clearance of creatinine.

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