True or False? True False 1. Proteins rapidly pass artificial membrane (liposome

ID: 7188 • Letter: T

Question

True or False? True False
1. Proteins rapidly pass artificial membrane (liposome). -------------------------------------------------------------------------------------- ( ) ( )
2. Amphiphatic detergent such as SDS spontaneously forms bilayer in water. ------------------------------------------------------------ ( ) ( )
3. Cholesterol does have a hydrophilic head and hydrophobic tail. ------------------------------------------------------------------------- ( ) ( )
4. Fat molecules are one of the major components of the plasma membrane. ------------------------------------------------------------- ( ) ( )
5. Phospholipid molecules such as phosphatidylcholine spontaneously form bilayer. ---------------------------------------------------- ( ) ( )
6. Flippase facilitates lateral movement of phospholipids within the plane of the membrane. ----------------------------------------- ( ) ( )
7. Glycolipids make bilayer less permeable to small water soluble molecules. ----------------------------------------------------------- ( ) ( )
8. Membrane inner leaflet is enriched with phosphatidylcholine, Sphingomyelin, and Glycolipid. ----------------------------------- ( ) ( )
9. Plasma membrane proteins can have an enzyme activity. -------------------------------------------------------------------------------- ( ) ( )
10. A single pass membrane protein must have an amphiphatic alpha helix. -------------------------------------------------------------- ( ) ( )
11. Plasma membrane proteins can be linked to a lipid molecule at the outer leaflet of the plasma membrane. --------------------- ( ) ( )
12. The lateral motility of membrane proteins can be restricted by tight junctions. ------------------------------------------------------ ( ) ( )
13. Channel proteins have specific binding sites for ions and thus slower than carrier proteins. --------------------------------------- ( ) ( )
14. An antiport would function as a symport if its orientation in the membrane were reversed. --------------------------------------- ( ) ( )
15. A transmembrane pore can be formed by multiple amphipathic alpha helices. ----------------------------------------- ( ) ( )
16. Porin proteins form water-filled channels in the outer membrane of a bacterium and are mostly composed of beta sheets. ---- ( ) ( )
17. Glucose uniporters localize at the apical side of the intestinal epithelium. ------------------------------------------------------------ ( ) ( )
18. GAP junction is a selective pore for anions. ----------------------------------------------------------------------------------------------- ( ) ( )
19. A voltage-gated Na+ channel adopts only two conformation states: open and closed. ----------------------------------------------- ( ) ( )
20. Voltage gated K+ channel opens faster than the Voltage gated Na+ channels. -------------------------------------------------------- ( ) ( )
21. Opening of chloride channel at the synapse will help to fire an action potential. ------------------------------------------------------ ( ) ( )
22. The nuclear pore complex forms a gate through which molecules pass the nucleus uni-directionally. -------------------- ( ) ( )
23. A completely folded protein is imported into a mitochondrion through a large non-selective pore. --------------------------------- ( ) ( )
24. ER signal sequence contains multiple lysine and arginine residues. ---------------------------------------------------------------------- ( ) ( )
25. The plasma membrane is a sorting station of inward endocytic pathway. ---------------------------------------------------------------- ( ) ( )
26. The trans Golgi functions as a sorting station of outward secretory pathway. ----------------------------------------------------------- ( ) ( )
27. Vesicles budding from ER are coated with Clathrin. ---------------------------------------------------------------------------------------- ( ) ( )
28. RabGTPases and tethering proteins are the major specificity determinant of vesicle transport system. -------------------------- ( ) ( )
29. v-SNARE proteins are one of the tethering proteins. ------------------------------------------------------------------------------------ ( ) ( )
30. In secretory cells, the constitutive and regulatory pathways of exocytosis diverge at the cis Golgi network. ------------------ ( ) ( )
31. Many proteins are posttranslationally glycosylated at tyrosine residues in the ER. ------------------------------------------------- ( ) ( )
32. Cells import LDL molecules exclusively through pinocytosis. ------------------------------------------------------------------------- ( ) ( )
33. Cells recycle LDL receptors from lysosome to the plasma membrane. ----------------------------------------------------------------- ( ) ( )
34. Phagosomes fuse with late endosome. ------------------------------------------------------------------------------------------------------ ( ) ( )
35. Small vesicles from ER near the plasma membrane can fuse with the plasma membrane upon bypassing Golgi apparatus. -- ( ) ( )
36. If a Sec mutant showed an accumulation of newly synthesized proteins at ER,
then the Sec gene is likely a component of vesicle-budding machinery of trans-Golgi network. ------------------------------------ ( ) ( )
37. A signal recognition particle is a single pass trans-membrane protein of the ER membrane. ---------------------------------------- ( ) ( )
38. Typical animals cells display higher levels of intracellular sodium than extracellular compartments. ------------------------------ ( ) ( )
39. Typical animals cells display higher levels of intracellular chloride than extracellular compartments. ----------------------------- ( ) ( )
40. The Na-K Pump is a GTPase that can adopt active and inactive conformational states. ----------------------------------------------- ( ) ( )
1. Phospholipase
C--ß
produces
phosphatidylinositol
3,4,5--trisphosphate
and
diacylglycerol.
(
)
(
)
2. PDGF
activates
GPCR.
--------------------------------------------------------------------------------------------------------------------------------------------------------------
(
)
(
)
3. Rho
is
an
example
of
heterotrimeric
G
proteins.
--------------------------------------------------------------------------------------------------
(
)
(
)
4. All
members
of
the
G
protein
coupled
receptors
interact
with
small
GTPase
Ras.
--------------------
(
)
(
)
5. Adrenaline
is
an
example
of
the
ligands
for
the
RPTK
family.
----------------------------------------------------------------
(
)
(
)
6. Ras
GEF
activates
RPTK.
------------------------------------------------------------------------------------------------------------------------------------------------------
(
)
(
)
7. PH
domain
containing
proteins
bind
to
activated
EGFR.
--------------------------------------------------------------------------------
(
)
(
)
8. Ligands
for
GPCR
proteins
induce
dimerization
of
the
receptor.
--------------------------------------------------------------
(
)
(
)
9. Grb2
is
an
adaptor
protein
that
binds
to
a
phospho--tyrosine
residue
of
activated
RPTK
through
a
PH
domain.
--------------------------------------------------------------------------------------------------------------------------------------------------
(
)
(
)
10. When
a
cell
is
expressing
a
large
number
of
dominant
negative
EGFR
proteins,
an
introduction
of
a
constitutively
active
Ras
mutant
will
allow
EGF
signaling.
--------------------------------------------------------------------------
(
)
(
)
11. PI3K
generates
phosphatidylinositol
3,4,5--trisphosphate
from
IP3.
--------------------------------------------------------
(
)
(
)
12. Calcium
inhibits
PKC.
------------------------------------------------------------------------------------------------------------------------------------------------------------------
(
)
(
)
13. cAMP
activates
PKA.
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
(
)
(
)
14. The
MAP
kinase
ERK
inhibits
MAP
kinase
kinases.
------------------------------------------------------------------------------------------
(
)
(
)
15. cAMP
is
an
example
of
a
first
messenger.
--------------------------------------------------------------------------------------------------------------------
(
)
(
)
16. All
7--Transmembrane
receptors
are
G
Protein
Coupled
Receptors.
--------------------------------------------------------
(
)
(
)
17. Both
Ga
and
Gß
subunits
of
the
heterotrimeric
G
protein
can
mediate
GPCR
signaling.
------
(
)
(
)
18. Both
Ga
and
Gß
subunits
of
the
heterotrimeric
G
protein
have
GTPase
activity.
------------------------
(
)
(
)
19. The
Gas
subunit
of
the
heterotrimeric
G
protein
suppresses
the
function
of
Adenylyl
cylase.
(
)
(

Explanation / Answer

1. Proteins rapidly pass artificial membrane (liposome). -FALSE
As liposomes behave as a lipid bilayer, proteins cannot pass through rapidly.
2. Amphiphatic detergent such as SDS spontaneously forms bilayer in water. -TRUE
3. Cholesterol does have a hydrophilic head and hydrophobic tail. -TRUE
4. Fat molecules are one of the major components of the plasma membrane. -TRUE
5. Phospholipid molecules such as phosphatidylcholine spontaneously form bilayer.-TRUE
6. Flippase facilitates lateral movement of phospholipids within the plane of the membrane.
7. Glycolipids make bilayer less permeable to small water soluble molecules. -FALSE

Flippases facilitate flip flop movement but not lateral movement
8. Membrane inner leaflet is enriched with phosphatidylcholine, Sphingomyelin, and Glycolipid.-FALSE

Glycolipids are found only in the outer leaflet
9. Plasma membrane proteins can have an enzyme activity.-FALSE

Plasma membrane proteins do not have enzyme activity
10. A single pass membrane protein must have an amphiphatic alpha helix.-TRUE
11. Plasma membrane proteins can be linked to a lipid molecule at the outer leaflet of the plasma membrane. -TRUE
12. The lateral motility of membrane proteins can be restricted by tight junctions. -TRUE
13. Channel proteins have specific binding sites for ions and thus slower than carrier proteins.-FALSE

Channel proteins are faster than carrier proteins as carrier proteins go through change in conformation
22. The nuclear pore complex forms a gate through which molecules pass the nucleus uni-directionally.-FALSE

molecules can pass in and out of the nucleus
23. A completely folded protein is imported into a mitochondrion through a large non-selective pore.-FALSE

The protein needs to be unfolded for transport into the mitochondrion and needs selection by a target sequence
35. Small vesicles from ER near the plasma membrane can fuse with the plasma membrane upon bypassing Golgi apparatus.-FALSE

The vesicles from ER are passed through Golgi for processing, hence they cannot fuse directly with the plasma membrane.
40. The Na-K Pump is a GTPase that can adopt active and inactive conformational states.-FALSE

It is an ATPase
4. All members of the G protein coupled receptors interact with small GTPase Ras.-TRUE
15. cAMP is an example of a first messenger.-FALSE

It is a secondary messenger
---

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True or False? True False 1. Proteins rapidly pass artificial membrane (liposome

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