True or False? If false, explain why. a) The ribosome moves along the mRNA in a

Question

True or False? If false, explain why.

a) The ribosome moves along the mRNA in a 5’ à 3’ direction

b) The overall structure of the ribozyme is dictated by rRNA

c) Ribosomes consist of 2/3 protein and 1/3 rRNA

d) Each ribosome has 1 large subunit and one small subunit

e) The small ribosomal subunit is the first to bind to the mRNA via the 5’ cap

f) RNA polymerase II is responsible for transcribing messenger RNA •

g) Combinatorial control of gene expression involves groups of transcriptional regulators working together to determine the expression of a gene

h) A nonsense mutation is a type of base pair substitution that leads to a change from one amino acid to a different amino acid.

Explanation / Answer

a) The ribosome moves along the mRNA in a 5’ à 3’ direction
The answer is True. Because the ribosomal binding regions such as kozak sequece is present at 5' side of the mRNA, it hinds there ans starts the translocation.

b) The overall structure of the ribozyme is dictated by rRNA
The answer is True. The fucntion of ribozyme is a part of the large subunit ribosomal RNA.

c) Ribosomes consist of 2/3 protein and 1/3 rRNA
The answer is False, becuase ribsome is composed with 60% rRNA and 40% protein which means 2/3 portion of rRNA and 1/3 portion of protein.

d) Each ribosome has 1 large subunit and one small subunit
The answer is True. Each ribosome is composed wiht two subunits they are reffered as large and small subunits.

e) The small ribosomal subunit is the first to bind to the mRNA via the 5’ cap
The answer is True. The small subunit of ribsome binds to the 5' utr region first along with transcription factor to intitiate the translation.

f) RNA polymerase II is responsible for transcribing messenger RNA
The answer is True.
RNA pol I synthesizes rRNA,
RNA pol II synthesizes mRNA,
RNA pol III synthesized tRNA.

h) A nonsense mutation is a type of base pair substitution that leads to a change from one amino acid to a different amino acid.
The answer is False. If mutation leads to change from one AA to other, it is reffered as missence mutation.

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