An intravenous dose of azithromycin is usually prepared by injecting a measured

Question

An intravenous dose of azithromycin is usually prepared by injecting a measured small amount of sterile water into a sealed vial containing a specific known amount of solid formulation containing the medication and shaking the vial until all of it is dissolved. Th e dosage to be administered to a patient is then removed (with a syringe) and added to a specifi c volume of diluent solution, which is then administered as an IV drip. A diluent solution that is commonly used is 1/2 normal saline (0.45% sodium chloride solution). If an azithromycin formulation contains 500 mg of azithromycin and sterile water is added to make 5 mL of the formulation, how much must be removed with the syringe to add to the diluent solution for a dosage of 80 mg?

Explanation / Answer

Formulation prepared = (500 mg/5mL)= 100mg/mL Now calculate the total volume that can be administered, 500mg * (1/100mg/mL) = 5 mL volume that must be removed with the syringe to add to the diluent solution for a dosage of 80 mg can be done using simple dose calculation, (desired mg / formulation mg) * total volume administered (80 mg/ 500mg) * 5mL = 0.8 mL

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