You discover a mutation in anti- IAPs in a tumor sample. The mutation is within

Question

You discover a mutation in anti-IAPs in a tumor sample. The mutation is within the IAP binding domain. You are trying to figure out whether you should treat this patient with a drug that is designed to induce apoptosis. What should you do and why?

Treat the patient with the drug, it will work to induce apoptosis in the tumor cells and this is a good thing

Dont bother. The patient will be resistant to the drug since the mutation will prevent activation of the intrinsic pathway.

Treat the patient with the apoptosis inducing drug because they should be very sensitive due the the mutation discovered in the ani-IAP gene. You expect apoptosis will occur at a high frequency.

Dont treat the patient with the drug, we dont want to induce apoptosis in this patient, they are already sick enough.

Treat the patient with the drug, it will work to induce apoptosis in the tumor cells and this is a good thing

Dont bother. The patient will be resistant to the drug since the mutation will prevent activation of the intrinsic pathway.

Treat the patient with the apoptosis inducing drug because they should be very sensitive due the the mutation discovered in the ani-IAP gene. You expect apoptosis will occur at a high frequency.

Dont treat the patient with the drug, we dont want to induce apoptosis in this patient, they are already sick enough.

Explanation / Answer

The inhibitors of apoptosis (IAP) proteins are a family of proteins that are involved in cell death, immunity, inflammation, cell cycle and migration.

Apoptosis can be activated via an extrinsic or death-receptor-mediated pathway and an intrinsic or mitochondrial pathway.

Answer: Treat the patient with the apoptosis inducing drug because they should be very sensitive due the the mutation discovered in the ani-IAP gene. You expect apoptosis will occur at a high frequency.

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