1. For each of the following proteins that are proteolytically cleaved in apopto
ID: 70754 • Letter: 1
Question
1. For each of the following proteins that are proteolytically cleaved in apoptosis, indicate which cleavage is first carried out by an executioner caspase
a. The initiator caspase-2
b. The executioner caspase-3
c. The BH3-only protein Bid
d. The endonuclease inhibitor iCAD
2. Which Bcl-2 family member links intrinsic apoptotic signals (cellular stress), such as DNA damage, infections, to mito-mediated cell death?
pro-apoptotic bcl2 proteins
BH3-only proteins.
Anti-apoptotic bcl2 proteins
Anti-apoptotic BH3-only proteins.
3. The apoptosome ....
Releases cytochrome c to the cytosol
Activates caspase 9
Is a wheel-like heptamer of Apaf2
Is an intracellular regulator
a.pro-apoptotic bcl2 proteins
b.BH3-only proteins.
c.Anti-apoptotic bcl2 proteins
d.Anti-apoptotic BH3-only proteins.
Explanation / Answer
Ans1. The executioner caspase 3 is first activated by initiator caspase which then triggers further apoptosis process.
2. BH3 only proteins links intrinsic apoptic signals such as DNA damage, infection,to and mito mediated cell death. A cascade of different BH3 only proteins lead to the apoptosis in order to overcome damage and to restrt the process correctly.
3. The apoptosome activated caspase 9 in response to the release of cytochrome c to the cytosol.
Related Questions
Navigate
Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.