Question XII. Lulu, a 22-year-old lion tamer, agreed to participate in a scienti

Question

Question XII. Lulu, a 22-year-old lion tamer, agreed to participate in a scientific experiment and was passively sensitized with IgE specific for a banana protein antigen Baproag 1 (allergen). When challenged with Baproag 1 intradermally, she displayed
a typical skin lesion due to an immediate hypersensitivity reaction. If the injection with sensitizing IgE was first preceded by an injection (at the same site) of Fc fragments of human IgE and then followed by the intradermal injection of Baproag 1, which of the following could possibly happen? Assess as either factually correct (= “true”) or incorrect (= “false”) the following possibilities (98-107):

NOTE THAT THE QUESTION ASKS WHICH COULD POSSIBLY HAPPEN. NOT WHICH IS MOST LIKELY

98. The reaction would be exacerbated due to the increased local concentration of IgE Fc fragments.
99. The reaction would be exacerbated due to the activation of complement.
100. The reaction would be exacerbated due to the augmented release of cytokines.

101. The reaction would be exacerbated due to the activation of macrophages and dendritic cells.
102. The reaction would be exacerbated, because the Fc fragments would activate NK cells.
103. The reaction would be exacerbated, because the Fc fragments would activate mast cells and/or basophils.
104. No reaction would occur, because the Fc fragments would interact with the allergen and prevent it from gaining access to the sensitized mast cells.
105. No reaction would occur, because the Fc fragments would interact with the IgE antibodies making their antigen-binding sites unavailable for binding to antigen.
106. No reaction would occur, because the Fc fragments would interact with FcRI receptors on mast cells.
107. Lulu would develop anaphylaxis.

Explanation / Answer

SOLUTION:

98. The reaction would be exacerbated due to the increased local concentration

of IgE Fc fragments.-True
99. The reaction would be exacerbated due to the activation of complement.-False

100. The reaction would be exacerbated due to the augmented release of cytokines.-True

101. The reaction would be exacerbated due to the activation of macrophages and dendritic cells.-False

102. The reaction would be exacerbated, because the Fc fragments would activate NK cells.-False

103. The reaction would be exacerbated, because the Fc fragments would activate mast cells and/or basophils. -True

104. No reaction would occur, because the Fc fragments would interact with the allergen and prevent it from gaining access to the sensitized mast cells.-True

105. No reaction would occur, because the Fc fragments would interact with the IgE antibodies making their antigen-binding sites unavailable for binding to antigen.-False

106. No reaction would occur, because the Fc fragments would interact with FcRI receptors on mast cells. -True

107. Lulu would develop anaphylaxis. -True

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