Abnormalities in cardiac output and blood pressure are often related in disease

Question

Abnormalities in cardiac output and blood pressure are often related in disease states. One of the most common methods to measure the flow rate of blood is called the indicator-dilution method. Using the indicator-dilution method, a dye is injected into the pulmonary artery and the concentration of this dye is monitored in the radial artery. The table below shows the concentration of the dye in the radial artery over time. 19.3 mg of dye was injected into the pulmonary artery of the patient. Determine the average flow rate in the circulatory system of this patient. Assume that all of the dye stays in the circulatory system. Concentration of Dve in Blood Time Sec 2.3 2.4 2.5 2.6 2.7 2.8 2.9 3.0 Concentration (mg/L 207 156 121 94.5 73.6 57.3 44.6 40.6 42.1 46.8 54.6 63.5 67.1 71.5 74.0 74.9 72.1 70.2 66.3 63.5 62.6 63.0 64.5 ne Concentration Time Sec 0.0 (mg/L 1.35 1.73 2.23 2.86 3.67 4.71 6.05 7.77 9.98 12.8 16.5 21.1 27.1 34.8 44.7 57.4 73.7 94.6 122 156 200 242 245 0.2 0.3 0.4 0.5 0.6 0.7 0.8 0.9 3.2 3.4 3.5 3.6 1.5 3.8 3.9 4.0 4.2 4.3 2.0 2.2 4.5

Explanation / Answer

Assume that the dye stays in the circulatory system and the quantity of dye injected is 19.3 mg.

Calculate the flow rate for individual field, for example: 19.3/(0.1*1.73)= 111.56 L/s

The average flowrate in the circulatory system of the patient= 4.839 L/s

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