The correct answer is option [E]. Aspartic acid is protonated at the beginning o

Question

The correct answer is option [E].

Aspartic acid is protonated at the beginning of reaction cycle in aspartyl process. The group similar to this function is Aspartic Acid 102.

Since asparate is acidic, it will be deprotonated first by bases. Aspartate that flanks the histidine residue also provides it with favorable electrostatic effects and makes it a better proton acceptor. So after asparate is deprotonated, proton transfer from histidine goes to aspartate. Now that histidine is deprotonated, it grabs the proton from serine's hydroxyl group. This creates a much more reactive alkoxide group on serine.

Explanation / Answer

Ignore the circle. which is right answer and why? 5. Which group in chymotrypsin has the same function as the aspartic acid that is protonated at the beginning of the reaction cycle in aspartyl proteases. A. Serine 195 The specificity pocket C. )Histidine 57 D. Aspartic acid 102 E. The oxyanion hole (amides of glycine 193 and serine 195)

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