AT&T; LTE ( 0 2196 [ O 12:15 AM blackboard.jhu.edu QUESTION 1 1 points Save Anwe

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AT&T; LTE ( 0 2196 [ O 12:15 AM blackboard.jhu.edu QUESTION 1 1 points Save Anwer Fruit flies develop as male, female, or "intersex" (a random mosaic of male and female tissues) animals depending on the outcome of a developmental switch. The developmental switch is controlled by a cascade of alternative splicing events that, according to Figure 13-23 in the textbook, produces two distinct repressors called doublesex-M in males and doublesex-F in females. Please refer to Figure 13-23 and try to answer questions 1-5 Mutations in sex-lethal and transformer can cause sex-reversal (XX females developing as males). Are these mutations usually recessive or dominant with respect to the wild-type allele? ORecessive sxl mutations and dominant tra mutations would likely lead to a sex reversal phenotype ORecessive tra mutations and dominant sxl mutations would likely lead to a sex reversal phenotype OSex reversal phenotype would likely be due to recessive mutations in either sxl or tra Sex reversal phenotype would likely be due to dominant mutations in either sxl or tra QUESTION 2 1 points Save Answer Briefly explain your choice in question 1 Path: p QUESTION 3 2 points Save Answer A mutation occurs in the doublesex gene that prevents Tra from binding to the unspliced dsx RNA transcript.

Explanation / Answer

1. The answer is sex reversal phenotype would likely be due to dominant mutations in either sxl or tra.

2. Sxl is activated in females (2X;2A) but not in males (X;2A) . Sxl expression in females is maintained by a positive autoregulatory loop such that Sxl positively controls its own expression . Loss-of-function mutations in most of these genes—Sex-lethal (Sxl), transformer (tra), and transformer-2 (tra2)—transform XX individuals into males. The Sxl gene regulates somatic sex determination by controlling the processing of the transformer (tra) gene transcript.

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