Human hemoglobin (first 30 amino acids) H) hltpeeksav talwgkvnvd evggealgrl A) m

Question

Human hemoglobin (first 30 amino acids)
H) hltpeeksav talwgkvnvd evggealgrl
A) mltaeekaav tafwgkvkvd evggealgrl
B) dwtdaeraai vslwgkinva eigpqalarl
C) hwtgeekalv navwtktdhq avvakalerl
D) hwtaeekqli tglwgkvnva ecgaealarl
E) hltpeeksav talwgkvnvd evggealgrl

Which sequence is the most related to human hemoglobin?
Which sequence is the least related to human hemoglobin?
Name an amino acid (position) that is conserved in all species above.

Answer the remaining questions from the chart below. Assuming amino acid changes in hemoglobin accumulate at about 1 change in a stretch of 30 amino acids every 25 million years, how long have differences been accumulating between humans and hemoglobin sequence A? between humans and hemoglobin sequence number C? Between sequences D and E? From the data and the chart below, what animal’s hemoglobin is
sequence D likely to be?

Match the animals’ hemoglobin sequences you studied above to the animals
below:

Chimp Shark Fish Cow Chicken

Explanation / Answer

Given data is

First 30 amino acids sequence of hemoglobin

          hltpeeksav talwgkvnvd evggealgrl

sequence that is most related to human hemoglobin is

E) hltpeeksav talwgkvnvd evggealgrl

sequence that is least related to human hemoglobin is

dwtdaeraai vslwgkinva eigpqalarl

( in this sequence there are more replacements between charged and uncharged amino acids).

The amino acid (position) that is conserved in all species is

Glutamate (e), 6th position.

If it takes 25 million years for one amino acid change in a stretch of 30 amino acids then

The number of years took place for differences to accumulate between humans and hemoglobin sequence A are

hltpeeksav talwgkvnvd evggealgrl

mltaeekaav tafwgkvkvd evggealgrl

- 5 changes so, 125 million years would take place for accumulating changes.

Between humans and hemoglobin sequence C

hltpeeksav talwgkvnvd evggealgrl

hwtgeekalv navwtktdhq avvakalerl

       - 16 changes so, 400 million years.

Between sequences D and E

hwtaeekqli tglwgkvnva ecgaealarl

hltpeeksav talwgkvnvd evggealgrl

-          10 changes so, 250 million years.

Depending on the number of differences in the hemoglobin sequence we can assume the animal to which sequence belongs.

Chimp are closer to humans.

Next comes fish, bovine, chicken and most distant sequence is of shark.

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