How does the immunoglobulin light chain germline DNA differ from that of the hea

Question

How does the immunoglobulin light chain germline DNA differ from that of the heavy chain? Which chain contributes the greater diversity to the antigen- binding specificities of immunoglobulin protein molecules? Why? How does the immunoglobulin light chain germline DNA differ from that of the heavy chain? Which chain contributes the greater diversity to the antigen- binding specificities of immunoglobulin protein molecules? Why? Which chain contributes the greater diversity to the antigen- binding specificities of immunoglobulin protein molecules? Why?

Explanation / Answer

How does the immunoglobulin light chain germline DNA differ from that of the heavy chain?

The light chain genes, offers the possibility of choice between similar, functional sequences. The Intergene recombination permit the long-term evolution of the locus with duplication or deletion of the genes. It also undergoes intragene conversion and recombination which leads to polymorphism between individuals. Due to presence of several ORF it further contribute to diversity.

Which chain contributes the greater diversity to the antigen- binding specificities of immunoglobulin protein molecules? Why?

The variable VDJ region in the light and heavy chain contributes to the greater diversity to the antigen - binding specificities of immunoglobulin protein. Apart from which the diversity also arise due to combination of heavy chains (6000) and light chain (160) light chains. Diversity also results due to somatic hyper mutations.

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