Which of the following statements correctly explain the huge diversity of antibo

Question

Which of the following statements correctly explain the huge diversity of antibody and T cell receptors? (choose all that are correct)

1.Imprecise joining at the junctions of all the V, D, and J segments.

2.Variable regions of light chains are joined by V and J segments while variable regions of heavy chains are joined by V, D, and J segments.

3.Variable regions of heavy chains are joined by V and J segments while variable regions of light chains are joined by V, D, and J segments.

4.Possible combinations of two species of light chains with one species of heavy chains.

5.Possible combinations of two species of heavy chains with one species of light chains.

Explanation / Answer

The two kinds of somatic rearrangements of DNA, which occur in the immunoglobulin gene loci, are V(D)J recombinations. The diversity in the structure of T cell receptor is mainly due to the influence of combinatorial and junctional diversity that is generated during the process of gene rearrangements. Most of the variability present in T cell receptor chain is present in the junctional regions. These junctional regions are encoded by V, D, and J gene segments.

The statements correctly explain the huge diversity of antibody and T cell receptors are as follows:

Thus, the correct options are (1), (2) and (4).

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