Upon Re-addition of a single glucose to (Man)9(GlcNac)2 which is already attache

Question

Upon Re-addition of a single glucose to (Man)9(GlcNac)2 which is already attached to the serine of a newly synthesized protein, the following event may occur:

Wrong Answer:

recognition by the SRP receptor

Answers:

recruitment of lexin proteins clareticulin and calnexin to facilitate folding and retention

activation of Get 3

recognition by the SRP receptor

entry into the translocon

Upon Re-addition of a single glucose to (Man)9(GlcNac)2 which is already attached to the serine of a newly synthesized protein, the following event may occur:

Wrong Answer:

recognition by the SRP receptor

Answers:

recruitment of lexin proteins clareticulin and calnexin to facilitate folding and retention

activation of Get 3

recognition by the SRP receptor

entry into the translocon

Explanation / Answer

The correct answer is "entry into the translocon", since proteins that achieve their native conformation exit the endoplasmic reticulum (ER) and continue through the secretory pathway.

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