What is the effect of each of the following treatments on the oxygen affinity of

Question

What is the effect of each of the following treatments on the oxygen affinity of hemoglobin A in vitro and why?

1. Increase in pH from 7.2 to 7.4
2. Increase in pCO2 from 10 to 40 torr 3. Increase in [2,3-BPG] from 2 x 10-4 to 8 x 10-4M 4. Dissociation of a2ß2 into monomeric subunits What is the effect of each of the following treatments on the oxygen affinity of hemoglobin A in vitro and why?

1. Increase in pH from 7.2 to 7.4
2. Increase in pCO2 from 10 to 40 torr 3. Increase in [2,3-BPG] from 2 x 10-4 to 8 x 10-4M 4. Dissociation of a2ß2 into monomeric subunits

Explanation / Answer

Oxygen affinity with hemoglobin is influenced by many factors which includes the following

- Temperature

- 2, 3 - BPG

- Carbon dioxide

- pH

Hemoglobin affinity towards oxygen will decrease with an increase in body temperature, hydrogen ion concentration, 2,3-bisphosphoglycerate or carbon dioxide concentration (the Bohr effect).

So, according to that the following effects are seen

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