The experiment below shows immunofluorescence of cAMP in growth cones. A shows r

Question

The experiment below shows immunofluorescence of cAMP in growth cones. A shows representative images of growth cones. B shows rigorous and stringent quantification of multiple images from multiple experiments. FSK, forskolin.

Question 19

What can you conclude from this data?

In the experiment below, neurons were treated with CB2 agonists and inverse agonists as before. They were also treated with H89 and KT5720, which are both PKA inhibitors. The growth cones were visualized by immunofluorescence of a neuron-specific protein.

Question 25

CB2 agonist decreased the effect of forskolin.

Question 26

CB2 inverse agonist decreased the size of the growth cone.

Question 27

The effect of CB2 inverse agonist was decreased by PKA inhibitor

Question 28

What can you deduce from the last two pieces of data taken together?

Question 29

What else can you deduce from these last two pieces of data?

Explanation / Answer

Q 19). CB2 most likely couples to Gi

CB2 most likely couples to Gi but does not likely couples to G

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