The amount of mRNA does not usually correlate with the amount of functional prot

Question

The amount of mRNA does not usually correlate with the amount of functional protein. Which of the following could decrease the amount of functional protein in the cell?

The rate of degradation is faster than the rate of translation.

The protein is not in the same compartment as its binding partners / substrates.

The protein does not have the appropriate post-translational modifications.

All of the above are possible.

The rate of degradation is faster than the rate of translation.

The protein is not in the same compartment as its binding partners / substrates.

The protein does not have the appropriate post-translational modifications.

All of the above are possible.

Explanation / Answer

All of the above are possible.

* If rate of degradation is faster than the rate of translation, the amount of that specific protein decreases

* If the proteins is not in the same compartment as its substrates, the protein is of no use, its stabilty decreases as it doesnt bind to any of its ligand

* Post translational modifications like glycosylation increases the half life of a protein and gives stabilty to the protein. Lack of these modifications lead to degradation of the protein.

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