Drug resistance is a huge problem with many infectious agents, especially Mycoba

Question

Drug resistance is a huge problem with many infectious agents, especially Mycobacterium tuberculosis. (a) Name two aspects of TB therapy that contribute to why resistance is occurring/arising so frequently in M. tuberculosis versus other pathogens? (b) What is one successful program/effort used by the World Health Organization (WHO) to decrease the accumulation of resistance? (c) Why is this program successful, even in less developed countries/regions? (d) What is it called when a cell suddenly becomes genetically different without any outside assistance or intervention? (e) Other types of bacteria often share antibiotic resistance genes with each other. What are three different ways by which this occurs? Drug resistance is a huge problem with many infectious agents, especially Mycobacterium tuberculosis. (a) Name two aspects of TB therapy that contribute to why resistance is occurring/arising so frequently in M. tuberculosis versus other pathogens? (b) What is one successful program/effort used by the World Health Organization (WHO) to decrease the accumulation of resistance? (c) Why is this program successful, even in less developed countries/regions? (d) What is it called when a cell suddenly becomes genetically different without any outside assistance or intervention? (e) Other types of bacteria often share antibiotic resistance genes with each other. What are three different ways by which this occurs? Drug resistance is a huge problem with many infectious agents, especially Mycobacterium tuberculosis. (a) Name two aspects of TB therapy that contribute to why resistance is occurring/arising so frequently in M. tuberculosis versus other pathogens? (b) What is one successful program/effort used by the World Health Organization (WHO) to decrease the accumulation of resistance? (c) Why is this program successful, even in less developed countries/regions? (d) What is it called when a cell suddenly becomes genetically different without any outside assistance or intervention? (e) Other types of bacteria often share antibiotic resistance genes with each other. What are three different ways by which this occurs?

Explanation / Answer

a) Aspects which contribute for drug resistance is - complex cell wall and drug modifying and inactivating enzyme present in M. TB.

b) STOP TB approach by WHO which has given DOTS plus course for all the patients affected for a course of six months so that accumulation of resistance is decreased.

c) It is successful due to free medication, hence all the affected individual are able to take the medicine.

d) It is a process of evolution where the organism changes itself so that it can survive better.

e) It occurs through conjugation, transformation and transduction.

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