RNA interference (RNAi) is a mechanism of gene silencing that is mediated by the

Question

RNA interference (RNAi) is a mechanism of gene silencing that is mediated by the presence of double-stranded RNA. Arrange the steps involved in gene silencing by RNAi.

Double-Stranded RNA (dsRNA) is introduced into a cell

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A gene's expression is silenced.

A.RNA-induced silencing complex (RISC) binds to short dsRNA

B. Antisense RNA pairs with the target RNA

C. Long dsRNA is cleaved into short dsRNA

D. The sense strand is separated from the antisense strand and degraded.

E. Target RNA is not trandlated.

Explanation / Answer

The order of the events is as follows:

1. Double-Stranded RNA (dsRNA) is introduced into a cell

2. Long dsRNA is cleaved into short dsRNA

3. RNA-induced silencing complex (RISC) binds to short dsRNA

4. The sense strand is separated from the antisense strand and degraded

5. Antisense RNA pairs with the target RNA

6. Target RNA is not translated

7. A gene's expression is silenced

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