RNA interference (RNAi) is a mechanism of gene silencing that is mediated by the

Question

RNA interference (RNAi) is a mechanism of gene silencing that is mediated by the presence of double MapdEb stranded RNA. Arrange the steps involved in gene silencing by RNAi Double-stranded RNA (dsRNA) is introduced into a cell. Target RNA is not translated A gene's expression is silenced. The sense strand is separated from the antisense strand and degraded. RNA-induced silencing complex (RISC) binds to short dsRNA Antisense RNA pairs with the target RNA. Long dsRNA is cleaved into short dsRNA. Previous Give Up & View Solution (O Check Answer O Next H Exit Hint RISC is activated only by short dsRNA.

Explanation / Answer

1. Double stranded RNA (dsRNA) is introduced into the cell.

2. Long dsRNA is cleaved into short dsRNA.

3. The sence strand is separted from the anti-sense strand and degraded.

4. RNA induced silencing complex (RISC) binds to short dsRNA.

5. Antisense RNA pairs with the target RNA.

6. Target RNA is not translated.

7. A gene's expression is silenced.

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