Robert unfortunately suffers from Huntington’s disease and Polycystic kidney dis

Question

Robert unfortunately suffers from Huntington’s disease and Polycystic kidney disease 2 (PKD2). Both are dominant conditions. Still, Robert manages to father many children with his healthy wife. Of his 18 children, 6 inherited both diseases, 6 didn’t any of these diseases, 3 inherited Huntington’s but not PKD2 and the remaining 3 kids inherited PKD2 but not Huntington’s. A) Are the genes for Huntington’s and PKD2 assorting independently? B) What could you say about their location on the chromosome?

Explanation / Answer

A) They are linked and therefore, can not assort independently. As they are linked, most of the kids (6+6=12) retain the same combination of genes in their gamets (wife is homozygous recessive) and therefore, 6 had both the disorders and 6 had none. There was, however recombination that made 3 kids each with one disease each.

B) They are linked and are on the same chromosome (In fact, the question B has already answered it by saying 'their' location on 'the' chromosome).

Related Questions

Navigate

• Browse (All)
• Browse R
• Subjects

Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.