TRUE/FALSE: 11. _____ Interferon induces the expression of various proteasome su
ID: 59660 • Letter: T
Question
TRUE/FALSE:
11. _____ Interferon induces the expression of various proteasome subuints leading to increased cleavage of peptides after hydrophobic residues.
12. _____ Defective Ribosomal products (DRiPs) are not used as a source of peptides for antigen presentation because they originate from inappropriately translated or transcribed genes.
13. _____ Transport of peptides from the proteasome into the endoplasmic reticulum is a passive process and does not require ATP hydrolysis.
14. _____ Only proteins that have not been modified by ubiquitin are capable of being degraded.
15. _____ Early after transcription of the MHC class I protein calnexin binds to and retains the protein in a partly folded state.
16. _____ Like T cells, B cells develop within the specialized organ known as the thymus.
17. _____ The common lymphoid progenitor, which arises from stem cells within the bone marrow, give rise to both developing B cells and T cells.
18. _____ The pTa is expressed on the cell surface of DN1 developing T cells.
19. _____ During negative selection the T cell receptor is selected against it ability to interact with the Major Histocompatibility Complex only.
20. _____ During both positive and negative selection T cells are selected against self-antigens.
Explanation / Answer
11. True .
12. False
13. True , it doenot require ATP .
14. False , it does require the ubiquitin to degrade through the ubiquitin lysosome pathway .
15. True it helps in the protein folding
16. False , they develop through the secondary lymphiod organs
17. True
18. False
19 False ,positive selection
20. False ,only negative selection T cells are selected agnaist the self antigens
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