TRUE/FALSE: 01. CD8 T cells recognize 13-amino acid peptides presented on MHC cl
ID: 59658 • Letter: T
Question
TRUE/FALSE:
01. CD8 T cells recognize 13-amino acid peptides presented on MHC class I molecules.
02. MHC class II molecules are loaded with peptides which originate from the cytosol.
03. The MHC class I molecule is composed of two polymorphic chains the a chain (composed of the a1-a2-a3 domain) and a smaller b2microglobulin chain.
04. TAP1 and TAP2 molecules form a transporter, which shunts partially degraded peptides from the cytosol into the endoplasmic reticulum.
05. The a2 and a3 domains of MHC class I bind to peptides.
06. The proteasome degrades proteins found in the cytoplasm and is a stable structure composed of subunits which are not replaceable.
07. HLA-DM binds to MHC class I molecule, releasing CLIP and allowing other peptides to bind within the endosome.
08. Cross-presentation is a process whereby phagocytosed material which normally would be loaded onto MHC class II molecules are loaded onto MHC class I molecules.
09. _____ MHC class I and MHC class II proteins once loaded with peptide are indefinitely express on the surface of the cell.
10. _____ MHC class II molecules are constitutively express by every cell of the body.
Explanation / Answer
1. False...
The CD8 T cells recognise 8-10 amino acid peptides presented on MHC class I molecule. The MHC class I molecule accomodates small proteins in its groove , which is narrow at the ends.
On the other hand 13-17 amino acid long peptides are accomodated in MHC class II molecule, whose groove is not narrow at the ends.
Related Questions
Navigate
Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.