12/8/2017 11:55 PM A 40/50 Gradebook -Print Calculator-dl Periodic Table Questio

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12/8/2017 11:55 PM A 40/50 Gradebook -Print Calculator-dl Periodic Table Question 10 of 10 Incorrect Map Sapling Learning macmillan learning Fructose-2,6-bisphosphate is a regulator of both glycolysis and gluconeogenesis for the phosphofructokinase reaction of glycolysis and the fructose-1,6-bisphosphatase reaction of gluconeogenesis. In turn, the concentration of fructose-2,6-bisphosphate is regulated by many hormones, second messengers, and enzymes How do the following affect glycolysis and gluconeogenesis? Activate glycolysis / Inhibit gluconeogenesis Activate gluconeogenesis/ Inhibit glvcolysis inhibition of PFK-2 increased levels of cAMP increased glucagon levels increased levels of fructose-2,6-bisphosphate inhibition of fructose-2,6-bisphosphatase (FBPase-2) Fructose-2,6-bisphosphatase cleaves a phosphate group from fructose-2,6-bisphosphate, yielding fructose-6-phosphate. If fructose-2,6-bisphosphate inhibits gluconeogenesis, consider the effect of fructose-2,6-bisphosphatase inhibition Previous Give Up & View Solution # Try Again Next Exit

Explanation / Answer

Solution

The following statments related to Fructose-2,6-bisphosphate affect glycolysis and gluconeogenesis:

1) Activate Glycolysis:

i) Increased levels of Fructose-2,6-bisphosphate

ii) Activation of PFK-2

2) Activate Gluconeogenesis:

i) Activation of Fructose-2,6-bisphosphate

ii) Increased levels of cAMP

iii) Increased glucagon levels

Explanation: PFK-2 is an allosteric enzyme that controls the formation of fructose-2,6-bisphosphate from the fructose-6-bisphosphate from with the expense of ATP to cAMP. The fructose-2,6-bisphosphate activates the function of PFK-2.

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