47. An X-linked dominant allele causes hypophosphatemia in humans. A man with hy

Question

47. An X-linked dominant allele causes hypophosphatemia in humans. A man with hypophosphatemia marries a normal woman. What proportion of their sons will have hypophosphatemia?

48.Dechenne muscular dsystrophy is sex-linked and usuallyaffects only males. Victims of the disease become progressively weaker, starting early in life.

a. What is the probability that a woman whose brother has Duchenne's disease wil have an affected child?

b. If your mother's brother (your uncle) had Duchenne's disease, what is the probability that you have recieved the allele

c. If your father's brother had the disease, what is the probabilty that you have recieved the allele?

52.

a What is the probability that a w has Duchenne's disease will have), n who ected h. If your mother's brother Duchennes have received the allele? brother our unde ne's disease, what is thechability c. If your father's brother had the d probubliy that you have received the allede e 19 A recently married man and woman discover had an uncle with alkaptonuria, os black urine discase," a rare disease caused by as somal recessive allele of a single gene. They as to have their first baby. What is the probabilin 50. The accompanying pedigree is concerns an inher a. What mode of inheritance best accounts for f transmission of this trait? b. Write the genotypes of all family members a ing to your hypothesis, 51. A couple who are about to get married lear in both thei lies, their unafected grandparents had s lies, their unaflected grandparents had sibling a II the couple marries t

Explanation / Answer

1. Let H be allele for hypophosphatemia and h allele is normal.

The parental phenotype is given as man with hypophosphatemia and woman normal for hypophosphatemia.

The parental genotype would be XhXh and XHY.

XhXh X XHY

   XHXh XhY XHXh XhY

All the offspring were normal. The Daughters were carriers of hypophosphatemia whereas sons are normal as it the X- linked disorder.

The probability of sons having hypophosphatemia is 0%

2.)

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