You have been studying the effects of vitamin D on gene expression. What kind of
ID: 58345 • Letter: Y
Question
You have been studying the effects of vitamin D on gene expression. What kind of receptor do you expect to be involved in this response?
Nuclear receptor
ion channel
enzyme linked receptor
GPCR
If you make a mutation in a G protein so that it cannot interact with it's alpha subunit or RGS protein, which of the following outcomes would be most likely?
phosphorylation of the GPCR
all are likely outcomes
constant activation of adenylyl cyclase and production of cAMP
Which of the following is/are an example of a latent gene regulatory protein that is regulated by cleavage or proteolysis?
STAT1/STAT2
RAS
SMADs
NFKB
If phosphorylation of an intracellular signaling molecule promotes signaling, then which enzyme would you expect to turn off signaling?
phosphatase
kinase
phospholipase
GTPase
You are studying the localization of a steroid hormone receptor in cells using fluorescent microscopy. You have tagged the receptor with GFP (green fluorescent protein) and are looking to see where the receptor goes under different conditions. You treat the cells with the cortisol. Where do you expect to find the green fluorescence?
cell surface
ER
nucleus
cytoplasm
Nuclear receptor
B.ion channel
C.enzyme linked receptor
D.GPCR
If you make a mutation in a G protein so that it cannot interact with it's alpha subunit or RGS protein, which of the following outcomes would be most likely?
A.phosphorylation of the GPCR
B.all are likely outcomes
C.constant activation of adenylyl cyclase and production of cAMP
D.Which of the following is/are an example of a latent gene regulatory protein that is regulated by cleavage or proteolysis?
A.STAT1/STAT2
B.RAS
C.SMADs
D.NFKB
If phosphorylation of an intracellular signaling molecule promotes signaling, then which enzyme would you expect to turn off signaling?
A.phosphatase
B.kinase
C.phospholipase
D.GTPase
You are studying the localization of a steroid hormone receptor in cells using fluorescent microscopy. You have tagged the receptor with GFP (green fluorescent protein) and are looking to see where the receptor goes under different conditions. You treat the cells with the cortisol. Where do you expect to find the green fluorescence?
A.cell surface
B.ER
C.nucleus
D.cytoplasm
Explanation / Answer
1. Nuclear receptor
Calcitriol is metabolite of vitamin D, which binds to the nuclear receptor.
4. Phosphatase.
Because signaling will be terminated by removal of phosphate, so phosphatase will be used.
5. Nucleus.
Steroid hormone receptor binds with the steroid and take it directly to the nucleus.
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