These are questions dealing with toxiological chemistry. 1 a)A particular compou

Question

These are questions dealing with toxiological chemistry.

1 a)A particular compound has a threshold of 20 mg/kg. What effect would be observed with an exposure of 10 mg/kg?

b) The enzyme catalase that can metabolize hydrogen peroxide forming two non toxic products. What are the two products?

c) Hydrogen peroxide can react with the iron II cation in the Fenton reaction. What are the two products of this reaction?

2) Three similiar compounds are being evaluated for toxic potential. The compounds differ in their n-octanol/water distribution rations. Compound A has a ratio of 1/20. Compound B has a ratio of 1/200.

a)Which compound would be most toxic to the brain and which would most raidly excrete through the kidneys?

3) Which is not true of glutathione?

a) used in detoxification of hydrogen peroxide

b) used in detoxificiation of electrophiles

c) used in detoxification of free radicals

d) used in detoxification of nucleophiles

Explanation / Answer

Q1 its all depends upon the average weight of man , interaction of drug with the substance present in our body during the time of exposure. Activity value of theta substance . it may be severe or non effective

Q 2 the two product are water and oxygen t

Q3 the compound s which is water soluble that is B will be readily excreted by kidney while the compound A will be more toxic for brain cells.

Q4 does not used in detoxification of nucleoPhil e

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