4·The three enzymes in the table below catalyze steps in the proline biosyntheti

Question

4·The three enzymes in the table below catalyze steps in the proline biosynthetic pathway. They are listed in alphabetical order, not in the order in which they appear in the pathway. I have also (very, very, very) roughly estimated G values for the reactions they catalyze. Which of these enzymes is most likely to be inhibited by proline? Explain your reasoning. Enzyme Glutamic-y-semialdehyde dehydrogenase y-Glutamyl kinase A'-Pyrroline-5-carboxylate reductase estimated AG for reaction -1 kJ/mol - 20 kJ/mol +2 kJ/mol

Explanation / Answer

The last enzyme, which has a positive dG value, will most likely be inhibited, this is because positive value for dG means that the reaction is not favorable thermodynamically in the forward direction. So the highest probability of getting inhibited is for this enzyme.

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