Below is a pathway showing the production of coat colour for a particular specie

Question

Below is a pathway showing the production of coat colour for a particular species of vole. The gene product of gene A is an enzyme that converts the white_1 substrate into the product white_2, while the gene product of gene B is an enzyme that converts the above white_2 product into a brown product: When two dihybrids (AaBb) are crossed together, what will be the predicted ratio of phenotypes in the offspring? When a dihybrid (AaBb) is testcrossed, what will be the predicted ratio of phenotypes in the offspring? What type of epistasis is outlined in this question?

Explanation / Answer

a. Predicted ratio of phenotypes in the offsprings is 15:1, which represents the duplicate dominant epistasis.

b. Predicted ratio of phenotypes in the offsprings of the test cross is 3:1

c. This type of epistasis is duplicate dominant epistasis. In this epistasis if a dominant allele of both gene loci produces the same phenotype without cumulative effect, i.e., independently the ratio will be 15:1.

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