* (10 marks) Many oral medications are absorbed in the stomach. Only the non-ion

Question

* (10 marks) Many oral medications are absorbed in the stomach. Only the non-ion of a drug is capable of simple diffusion from the stomach to the bloodstream. non-ionized drug that forms in the stomach after ingestion is known as the diffusion fraction, f, which ranges from 0 to 1. The fraction of Since many medications are weak acids or bases, the ratio of non-ionized (NI) to ionized () drug concentrations formed in the stomach lumen following ingestion can be predicted from the Henderson-Hasselbalch equation NI pKa-pH=log Medication pKa diazepam 3.3 enalapril 5.5 furosemide 3.9 lidocaine 7.9 naproxen 4.5 phenobarbital 7.4 Net absorption of medication into the bloodstream continues until equilibrium is established between the concentration of non-ionized drug in the stomach, [NI),, and the concentration of non-ionized drug in the blood, INIb. This is shown schematically in Figure 1. Page 1 of 3

Explanation / Answer

Answer no.(5)-Weak acid having strongest conjugate base. For weak acid Ka is less so Pka is more . Lidocaine having highest Pka value so its Ka value is lowest so it is a weak acid so it's conjugate base will be strongest .

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