There is a protein called Cyclin whose expression levels fluctuate with each cel

Question

There is a protein called Cyclin whose expression levels fluctuate with each cell division cycle even though its mRNA levels do not change. Now imagine there is a mutation in the CYCLIN gene such that the levels of both the Cyclin mRNA and Cyclin protein are constant. Which mutation in CYCLIN best explains these results?

A. The mutation is at a splice site that prevents splicing of the RNA transcript.

B. The mutation changes the ATG start codon to CCA.

C. The mutation is a deletion in the sequence that codes for the site in the protein to which ubiquitin is attached.

D. The mutation introduces a stop codon that truncates the protein at the fourth amino acid.

Explanation / Answer

c. deletion in the sequence that codes for the site in the protein to which ubiquitin is attached leads to the production of protein, which due to ubiquitin degraded and hence there will never be increase in the protein level.

so the mRNA Cyclin and Cyclin produced will remain constant.

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