Amino Acid Sequence and Protein Structure Our growing understanding of how prote

Question

Amino Acid Sequence and Protein Structure Our growing understanding of how proteins fold allowsresearchers to make predictions about protein structure based on primary amino acid sequence data. Consider the following amino acid sequence. 2. le Ala His Thr Tyr Gly Pro Phe Glu Ala Ala Met Cys Lys Trp Glu Ala Gin Pro Asp Gly Met Glu Cys Ala Phe His Arg a) Where might bends or b turns occur? b) Where might intrachain disulfide cross-linkages be formed? c) Assuming that this sequence is part of a larger globular protein, indicate the probable location (the external surface or interior of the protein) of the following amino acid residues: Asp, lle, Thr, Ala, Gln, Lys. Explain your reasoning

Explanation / Answer

a)

glycine- Proline (position 6 and 7) form beta turns

b)

Disulfide bridge can form between the sulfhydryl groups of Cystiene13- cysteine 24

c)

According to hydropathic index

Hydrophilic: lysine, Asp, glutamine, threonine

Hydrophobic: Ile, Ala

The hydrophilic amino acid residues are most likely to be found on the exterior of the globular protein, while the hydrophobic amino acids in the interior of the globular protein.

Related Questions

Navigate

• Browse (All)
• Browse A
• Subjects

---

---

Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.