One of the steps of glycolysis is the conversion of 3-phosphoglycerate to 2-phos

Question

One of the steps of glycolysis is the conversion of 3-phosphoglycerate to 2-phosphoglycerate, catalyzed by phosphoglycerate mutase (PGM).

1. Does the reaction involve an overall change in oxidation state?   If so, does the molecule become more or less oxidized?

2. Does the oxidation number change of the carbon atom to which the phosphate is attached? (i.e., does C3 in 3PG have a different oxidation number than C2 in 2PG?) If so, does it become higher or lower?

3. What would be the ratio of 3PG to 2PG if the reaction were at equilibrium at 25°C? (G°’ = +4.7 kJ/mol G = -0.6 kJ/mol.)

4. What is the actual ratio of 3PG to 2PG in heart muscle (T = 37°C)

phosphoglycerate mutase (PGM) H- OPO% 3 3-Phosphoglycerate (3PG) 2-Phosphoglycerate (2PG) © 2008 John Wiley & Sons, Inc. All rights reserved.

Explanation / Answer

1. No there is no overall change in oxidation state.
Phosphoglycerate mutase (PGM) catalyzes the phosphate shifts from C3 of 3-phosphoglycerate to C2 to form 2- phosphoglycerate. Since, there is only internal transfer of a phosphate group from 3PG to 2-phosphoglycerate (2PG) there is no overall change in oxidation state.

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