The following table lists allele frequencies for 4 STR loci in U.S. Caucasians.
ID: 55317 • Letter: T
Question
The following table lists allele frequencies for 4 STR loci in U.S. Caucasians.
A) What is the probability of matching a Caucasian suspect genotype if the genotype at the crime scene were NCSBI10NCSBI10, VDFS7VDFS7, PC/BT10PC/BT10, PBSO11PBSO11?
B) What is the Odds ratio for this number and how would this be interpreted?
C) What would increase your confidence in a match between the crime scene and a suspect?
D) How would the data in this table limit your investigation if nothing was known about the suspect?
NCSBI
VDFS
PC/BT
PBSO
Allele
Frequency
Allele
Frequency
Allele
Frequency
Allele
Frequency
14
0.006
14
0.002
15
0.017
13
0.052
13
0.076
13
0.078
14
0.017
12
0.306
12
0.300
12
0.359
13
0.060
11
0.379
11
0.291
11
0.279
12
0.300
10
0.228
10
0.293
10
0.239
11
0.303
9
0.026
9
0.024
9
0.032
10
0.300
8
0.006
8
0.010
8
0.008
9
0.003
7
0.003
NCSBI
VDFS
PC/BT
PBSO
Allele
Frequency
Allele
Frequency
Allele
Frequency
Allele
Frequency
14
0.006
14
0.002
15
0.017
13
0.052
13
0.076
13
0.078
14
0.017
12
0.306
12
0.300
12
0.359
13
0.060
11
0.379
11
0.291
11
0.279
12
0.300
10
0.228
10
0.293
10
0.239
11
0.303
9
0.026
9
0.024
9
0.032
10
0.300
8
0.006
8
0.010
8
0.008
9
0.003
7
0.003
Explanation / Answer
STR is short tandem repeats sequences used as genetic markers in forensic investigation. They are used because of length polymorphism in DNA sequences i.e; of differences in number of tandem repeats of nucleotide sequences. STR are used in forensic applications for further automation and miniaturizing DNA typing due to their nature of amplifying specific loci.
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