You have a sample muscle where the intracellular concentrations of K + and Na +

Question

You have a sample muscle where the intracellular concentrations of K+ and Na+are 170 mM and 13 mM respectively. Your extracellular concentrations are 5.5 mM for K+ and 220 mM for Na+. The chloride ions are passively distributed, with Em = ECl. Your PNa is 1/20 of PK.

a) Rounding to the nearest mV, what is the Em?

b) The extracellular concentration of Cl- is 225 mM. What is its intracellular concentration (round to two significant figures)?

c) What is the Em of this muscle when it is bathed in low sodium saline with Na+concentration of 103 mM? Concentrations of K+ and Cl- remain unchanged.

d) Following from part c, what ion or ions will move in what direction across the membrane as the new potential develops?

Please show ALL OF THE MATH you use for this, step by step! Even parts that may seem simple or obvious! I'm very bad at math but I need to know how to work this kind of problem out on my own. Thank you very, very much in advance!

Explanation / Answer

a)

b)

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