1. Which of the following is an effective and inexpensive screen for Galactosemi
ID: 53905 • Letter: 1
Question
1.
Which of the following is an effective and inexpensive screen for Galactosemia?
Affinity chromatography
Clinitest
Glucose oxidase
Hexokinase
Polarographic electrode
2,
Glycated hemoglobin is measured in units of:
gram %.
milligram %.
% of total hemoglobin.
% of total protein.
3.
A 3-month-old infant was admitted to pediatric service with a diagnosis of failure to thrive. A glucose and copper reduction test performed on the baby's urine gave the following results:
Glucose by dipstick (glucose oxidase test): negative
Glucose by copper reduction test: positive
Which of the following statements is most correct?
The copper reduction test result is due to an interfering substance of no clinical significance.
The dipstick result for glucose is correct and therefore the copper reduction test should not have been done.
The copper reduction test and glucose results most likely indicate the presence of a reducing substance other than glucose.
The glucose result is incompatible with the copper reduction test results and, therefore, an error.
4.
When an ion selective electrode interacts with its analyte, it produces a change in the electrode's
Conductance
Current
Resistance
Voltage
5.
HER2/neu DNA fluorescent probes are added to a reaction chamber containing the patient's cells. Hybridization occurs where the probe is the exact compliment to the DNA sequence in the cell, resulting in fluorescence when viewed under a fluorescent microscope. This describes:
PCR.
PCR-RT.
FISH.
direct fluorescent immunoassay.
a.Affinity chromatography
b.Clinitest
c.Glucose oxidase
d.Hexokinase
e.Polarographic electrode
Explanation / Answer
1. The inexpensive and effective screen for galactosemia is Clinitest (b).
2. The answer is % of total hemoglobin (c).
3. The correct answer is The copper reduction test and glucose results most likely indicate the presence of a reducing substance other than glucose (c). The dipstick mainly indicates the presence of only glucose, but copper reduction test will detect any reducing sugar including glucose.
4. The answer is voltage (d). In an ion-selective electrode, ionic analyte reacts with an electrode surface producing a change in potential (voltage) across the selective membrane. No current is allowed to flow.
5. The answer is FISH (Fluorescent In-Situ Hybridization) (c).
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