Of the following acidic compounds with given pKa values, which would have the lo

Question

Of the following acidic compounds with given pKa values, which would have the lowest degree of protonation at pH = 4.3? Acetic acid: pKa = 4.75 Benzoic acid: pKa = 4.19 Lactic acid: pKa = 3.86 All would be essentially completely deprotonated. Not enough information to find the answer. If a drug is designed to block the action of a particular enzyme, what would happen if the drug-enzyme interaction had a very high dissociation constant? Binding to the enzyme would require larger dosages of the drug. The drug would bind so tightly it would never dissociate, effectively blocking the enzyme. The drug would be degraded quickly by the enzyme. The drug would enhance the action of the enzyme rather than blocking it. The dissociation constant is not relevant, what matters is the particular drug structure.

Explanation / Answer

2. Smaller the pKa higher the acidic nature. Hence,

(3) lactic acid having smaller pKa than the given pH, gets more deprotonated than protonation.

3.

A. Binding to the enzyme would require larger dosage of drug.

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