You discover a mutation that causes mice to develop cramps in their legs. A fema

Question

You discover a mutation that causes mice to develop cramps in their legs. A female mouse of a true-breeding strain that develops cramps is mated with a male of a true-breeding non-cramp strain. All progeny develop cramps in their legs. Which of these procedures would you use to provide evidence for your hypothesis that twitchiness is due to mtDNA?

A) breed crampy male progeny with normal females to show no paternal inheritance B) breed a crampy female with a crampy male F1 mouse to verify there is maternal inheritance C) sequence the nuclear genome of the crampy male offspring D) sequence the mtDNA of the normal father E) backcross crampy female offspring with normal fathers

Explanation / Answer

* All the progeny developed cramps indicates it is mitochondrial inheritance from the mother. If the male has a mitochondrial trait, none of his offspring inherit it.

* To confirm the above said trait is due to mtDNA, breed crampy male progeny with normal females. If none of the progeny inherit the trait, it proves it is maternal inheritance.

Option A) is the correct answer.

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