Transcription of glutamine synthetase occurs under which conditions? When glutam

Question

Transcription of glutamine synthetase occurs under which conditions?                  

                                When glutamine levels are high, NtrB is autoinhibited, and NtrC can't bind the Gln enhancer

                                When glutamine levels are low, steric hinderance and autoinhibition are relieved in NtrB, NtrB binds to and phosphorylates NtrC causing it to bind to the Gln enhancer

                                When glutamine levels are low, steric hinderance and autoinhibition are relieved in NtrB, NtrB binds to and phosphorylates NtrC causing it to bind to the Gln enhancer

                                Glutamine levels are low NtrC phosphorylates NtrB and glutamine directly binds to the Gln enhancer

                                When glutamine levels are high, NtrB is autoinhibited, and NtrC can't bind the Gln enhancer

                                When glutamine levels are low, steric hinderance and autoinhibition are relieved in NtrB, NtrB binds to and phosphorylates NtrC causing it to bind to the Gln enhancer

                                When glutamine levels are low, steric hinderance and autoinhibition are relieved in NtrB, NtrB binds to and phosphorylates NtrC causing it to bind to the Gln enhancer

                                Glutamine levels are low NtrC phosphorylates NtrB and glutamine directly binds to the Gln enhancer

Explanation / Answer

Ans. When glutamine levels are low, steric hinderance and autoinhibition are relieved in NtrB, NtrB binds to and phosphorylates NtrC causing it to bind to the Gln enhancer.

Explanation: Synthesis of this enzyme is regulated by a protein called Nitrogen regulator protein-C (Ntr-C). The Ntr-C is by itself inactive, but gets activated, when another protein called Ntr-B, which is a kinase, phosphorylates Ntr-C to Ntr-C-p.The activated Ntr-Cp has an important role in enhancing transcriptional efficiency of several operons by several folds. It regulates nitrogen metabolism and its related genes, under starvation. It acts on more than 25 operons controlling more than 75 genes. The Ntr C is considered as a Regulon. The said protein becomes a dimer; it is in this state it binds to regulatory regions of the DNA of the gene.

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