22. Where on the enzyme does the inhibitor bind? 23. Are there any requirements

Question

22. Where on the enzyme does the inhibitor bind? 23. Are there any requirements of the enzyme in order for the inhibitor to bind? 24. Does the Vmax for the enzyme change in the presence of an uncompetitive inhibitor? Look at the graph for help with this. 25. If Vmax does change, does it increase or decrease in the presence of an uncompetitive inhibitor? 26. Does Km change in the presence of an uncompetitive inhibitor? Look at the graph for help with this. 27. If Km does change, does it increase or decrease in the presence of an uncompetitive inhibitor? 28. Based on what you have Just determined about Vmax and Km in the presence of an uncompetitive inhibitor, sketch what a [S] vs. Vo plot would look like (on the same plot, sketch a curve for each without and with inhibitor).

Explanation / Answer

22. The given is a type of non-competitive inhibition. In non-competitive inhibition, inhibitor molecules bind to the allosteric site on the enzyme (but does not compete for the substrate binding site), irrespective of whether the enzyme is already bound with a substrate or not.

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