5-Fluorouracil inhibits the formation of nucleotides containing the base a. aden

Question

5-Fluorouracil inhibits the formation of nucleotides containing the base a. adenine b. cytosine c. guanine d. thymine 6-Mercaptopurine mimics the base adenine, forming a pseudonucleotide and thus slowing a. cell-mediated immune reactions b. DNA synthesis c. RNA transport d. viral replication Methotrexate is a folic-acid antagonist that slows a. cell division b. cell-mediated immune reactions c. transport of nutrients to the cancer cell d. viral replication Cisplatin inhibits cell division by a. being incorporated in RNA b. binding to DNA and blocking its replication c. halting viral replication d. substituting for cytosine in a nucleotide Which of the following anticancer drugs was once used as a chemical warfare agent? a. cisplatin b. methotrexate c. nitrogen mustards d. vinblastine

Explanation / Answer

1. d) thymine

It blocks synthesis of the pyrimidine thymidine.

2. b) cell-mediated immune reactions

It inhibits several reactions involving inosinic acid.

3. a) cell division

Methotrexate leads to inhibition of DNA synthesis and hence inhibition of cellular replication.

4. b) binding to DNA and blocking its replication

Cisplatin interferes with DNA replication, killing the cancerous cells.

5. c) Nitrogen mustards

Nitrogen mustards are cytotoxic chemotherapy agents similar to mustard gas used in warfare.

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