Question 11 of 21 Map do Sapling Learning Sort the following examples and phrase

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Question 11 of 21 Map do Sapling Learning Sort the following examples and phrases based on whether they describe glucogenic amino acids, ketogenic amino acids, or both glucogenic and ketogenic amino acids. Click here to view a table of amino acids. Note: If you answer any part of this question incorrectly, a single red X will appear indicating that one or more of the phrases are sorted incorrectly. Both Ketogenic Glucogenic histidine phenylalanine directly converted converted to citric acid can be catabolized to cycle intermediates to release free energy acetyl-CoA lysine valine O Previous 8 Give up & View Solution Check Answer Next Exit

Explanation / Answer

Ans. I. Glucogenic: Histidine, Valine

II. Ketogenic: Lysine, directly converted to acetyl-CoA.

III. Both: Phenylalanine, Converted to citric acid intermediates, can be catabolized to released energy

II. An amino acid producing acetyl-CoA or Acetoacetyl-CoA is called ketogenic amino acid because as a citric acid cycle intermediates (Acetoacetyl CoA can be converted to Acetyl-CoA) it can further produce fatty acids or ketone bodies. Leucine and Lysine are the only amino acids acting as ketogenic amino acid in true sense.

I. The amino acids namely Alanine, Arginine, Asparagine, Aspartate, Cysteine, Glutamate, Glycine, Histidine, Methionine, Proline, Serine, and Valine give rise to succinyl-CoA. These amino acids, with respect to the fact that they produce succinyl-CoA, are glycogenic amino acids. An amino acid producing succinyl-CoA (or, a-ketoglutarate, fumarate, oxaloacetate and pyruvate) are called glucogenic amino acids because these citric acid cycle intermediates can further be used to synthesize glucose. During catabolism, the carbon skeletal of these amino acids may be converted to pyruvate or TCA intermediates for the purpose of glycogenesis. The catabolized intermediates may also be used to energy production, if needed.

III. Five amino acid can act as both glucogenic and ketogenic amino acid depending on the citric acid cycle intermediate they form. Example includes Tyrosine, Isoleucine, Tryptophan, Phenylalanine and threonine. All the amino acids, including ketogenic, glucogenic or both can be used to produce cellular energy when needed.

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