3. The weight percent of water in methanol can be measured by capillary column G

Question

3. The weight percent of water in methanol can be measured by capillary column GC using a nonpolar stationary phase and a thermal conductivity detector. A series of calibration standards gave the following results.
The w/w percent of H2O in a freeze-dried antibiotic is determined in the following manner. A 0.175-g sample is placed in a vial along with 4.489 g of methanol. Water sample is extracted into the methanol. Analysis of the sample gave a peak height of 13.66. What is the w/w percent of H2O in the antibiotic?
3. The weight percent of water in methanol can be measured by capillary column GC using a nonpolar stationary phase and a thermal conductivity detector. A series of calibration standards gave the following results. %w/w H,O ak height (arb, units) 1.15 0.00 0.0145 2.74 6.33 0.0472 0.0951 11.58 0.1757 20.43 0.2901 32.97 The w/w percent of H20 in a freeze-dried antibiotic is determined in the following manner. A 0.175-g sample is placed in a vial along with 4.489 g of methanol. Water sample is extracted into the methanol. Analysis of the sample gave a peak height of 13.66. What is the wiw percent of Hzo in the antibiotic?

Explanation / Answer

w/w percent of H2O in a freeze-dried antibiotic

0.175 g sample with 4.489 g methanol

Analysis gave peak height = 13.66

From the calibration points,

% water in the antibiotic sample = 0.0951 x 13.66/11.58

                                                   = 0.1122%

Thus,

%w/w water in the sample of freeze-dried sample of antibiotic is found to be about 0.1122%

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