35. In Drosophila, vermilion is a an X-linked mutation which changes the eye col

Question

35. In Drosophila, vermilion is a an X-linked mutation which changes the eye color. This mutatio recessive and the wild type allele is dominant. Males with normal color of their eyes were mutageni and then mated with vermillion-eyed females. The following progeny was obtained: 10, 007 males vermilion eyes; 9,991 females with wild type eyes; and 2 females with vermilion eyes. What is a mutation rate from the wild type allele to the vermillion allele in father's gametes? A) 0.02% B) 0.01% C) 0.002% D) 0.001% E) 0%

Explanation / Answer

Mutation rate is given by "a" calculated as:

a= h/ N ------- (1)

here, N = total number of individuals in population

h = Number of mutation hits/cell

In father's gametes h for mutation of wild type allele can be calculated as:

Number of male mutant individuals / Total number of individuals in the population

= 10007/ 20000 = 0.5

now using (1) to calculate mutation rate we get

a= h/ N

=0.5 / 20000 = 0.000025

= 0.002%

As per calculation mutation rate is 0.002%. Answer should be C in this case.

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