Why has it been so difficult for researchers to develop effective antivirals for
ID: 49544 • Letter: W
Question
Why has it been so difficult for researchers to develop effective antivirals for HIV?
because the virus is able to produce DNA as an intermediate in viral replication
because HIV has a high mutation rate
due to the damaged helper T cells that are targets for HIV
because evolution favors a rapidly expanding viral population
because HIV is a sexually transmitted viral disease
because the virus is able to produce DNA as an intermediate in viral replication
because HIV has a high mutation rate
due to the damaged helper T cells that are targets for HIV
because evolution favors a rapidly expanding viral population
because HIV is a sexually transmitted viral disease
Explanation / Answer
Because HIV has a high mutation rate
HIV contains a a fast procreative rate,very high mutation rate , & a huge population size. which suggests that at any given time, somebody's infected with HIV is carrying tens of lots of HIV virions with lots of completely different random mutations. Inevitably, later or sooner, a mutation can occur that confers resistance to ZDV. (This can generally be a mutation that causes larger property within the situation of the polymerase catalyst.) Notice that the HIV population has polygenic variation for resistance to ZDV before exposure to ZDV. However, at this stage the resistance to ZDV happens solely in one or a couple of virions, out of the billions.
Step 2 is for the patient to start taking ZDV. This stops or slows replication of many HIV virions, and people strains dies out. however the lucky particle with the proper mutation can survive and can be able to replicate.
The extant HIV virions then repopulate the host. shortly the complete HIV population consists of resistant virions.
Related Questions
drjack9650@gmail.com
Navigate
Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.