Why has enzyme replacement therapy not been as effective for lysosomal storage d
ID: 162108 • Letter: W
Question
Why has enzyme replacement therapy not been as effective for lysosomal storage disorders that affect brain tissue?
The enzymes can't get across the blood brain barrier.
the enzymes usually break up in the acidic environment of the stomach
All of the above.
The enzymes are metabolized by the liver prior to them becoming effective
The enzymes a filter by the kidney too quickly to reach the brain
The enzymes can't get across the blood brain barrier.
the enzymes usually break up in the acidic environment of the stomach
All of the above.
The enzymes are metabolized by the liver prior to them becoming effective
The enzymes a filter by the kidney too quickly to reach the brain
Explanation / Answer
ans A
Lysosomal storage disorders are the group of disorders resulting from the deficiency of single acid hydrolase. Enzyme replacement therapy has not been successful to treat disorder affecting brain tissues as the enzymes cannot cross blood brain barrier.
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