Shown below is the pedigree of a rare neurodegenerative disease in h umans. 10 1

Question

Shown below is the pedigree of a rare neurodegenerative disease in h umans. 10 11 12 13 If IV 9 10 11 12 13 14 a. Based on the pedigree, characterize each of the following modes of inheritance as likely, unlikely, or impossible: autosomal dominant, autosomal recessive, Y linked, X-linked dominant, and X-linked recessive. Justify your reasoning Further scrutiny of members of this family reveals the following: 1) The disease's degree of expression varies among individuals, with some mildly affected, others moderately affected and still others severely affected; and 2 Individual III-14 was previously married. Her ex-husband is phenotypically normal, with no history of the disease in his family going back ten generations. He has custody of the couple's two children, a girl and a boy, both of whom are affected with the disease. The partial pedigree is shown below (the "slash" represents separation or divorce) IV 16 b. Do these findings eliminate any of the remaining "likely or unlikely" modes of inheritance listed in part (a)? Are any of these modes of inheritance still possible? If so, which one and why? c. Is mitochondrial inheritance a likely, unlikely or an impossible mode of inheritance for this disease? Does it provide an explanation for the disease's variable expressivity? d. How can mitochondrial inheritance explain individual III-1

Explanation / Answer

a) autosomal dominant means even if the female is carrier then also the next generation shows the trai tin it , same is with the x linked dominant , if only males are being effect then y linked inheritance is there. but if the female in the next generation doesnot show the effect then x linked recessive is the answer for that case

these type of inheritance is not sex linked it can be a mitochondrial inheritance. when mitochondrial genome is transfered from one generation to another. if sex linked inheritance is there then the next generation can't show th trait maximum they can be carrier.

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