1) Loss of troponin T from the thin filament will result in which of the followi

Question

1) Loss of troponin T from the thin filament will result in which of the following?

a) No crossbridge activity with increases in calcium

b) Contunially active crossbridge cycling in the absence of calcium

c) Shorter thin filaments

d) Loss of tropomyosin

e) There is no effect on control of crossbridges

2) Blebbistatin is a newly identified small molecule inhuibitor of myosin heavy chain. Scientists determined that it binds to the myosin-ADP-Pi complex with high affinity and inhibits ADP-Pi release. What step of cross bridge function is affected?

a) ATP binding to the myosin head

b) Myosin binding to actin

c) Release of bound myosin from actin

d) cross bridge movement

e) It causes rigor mortis.

3) The muscle contraction with the highest maximum velocity of shortening occurs under what conditions?

a) Only when lifting the heaviest load

b) Only in the shortest muscles

c) Only in the muscles with the highest number of mitochondria

d) Only under unloaded conditions

e) Only in the hamstring muscles

4) There is a disease in which skeletal muscle cannot store glycogen. What would you predict as an outcome?

a) Increased muscular endurance

b) Less reliance on the liver for glucose during contractions

c) More reliance on the liver for glucose during contractions

d) Increased muscle strength

e) Changes in the length: tension relationship

5) Caffeine is a known agonist of the ryanodine receptor in muscle. If you put caffeine on a single muscle fiber you would expect the following to happen?

a) Generation of an action potential

b) Changes in DHPR status along the t-tubule

c) Increased SERCA activity

d) Hypertrophy of the muscle fiber

e) Decreased calcium levels outside the cell

Explanation / Answer

Loss of troponin T from the thin filament will result in which of the following Answer is (c) Shorter Thin Filaments Blebbistatin is a newly identified small molecule inhuibitor of myosin heavy chain. Scientists determined that it binds to the myosin-ADP-Pi complex with high affinity and inhibits ADP-Pi release. What step of cross bridge function is affected. Answer is (b)  Myosin binding to Actin The muscle contraction with the highest maximum velocity of shortening occurs under what conditions? Answer is (a)  Sarcomeric structure will be in a total state of disarray There is a disease in which skeletal muscle cannot store glycogen. What would you predict as an outcome? Answer is (a) Generation of an action potential Caffeine is a known agonist of the ryanodine receptor in muscle. If you put caffeine on a single muscle fiber you would expect the following to happen? Answer is (a) Decreased number of sarcomeres in series.

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